Subscribing to this thread. Creatine kinase is exactly what I've been researching. 🙏

Slightly tangential to Creatine kinase but Dr.EndoIndy reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Saving this for reference. Top-tier content.

Want to share my personal experience related to Creatine kinase elevations on since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 253 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 12 months later: I am down 83 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The Creatine kinase aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

Relevant to Creatine kinase elevations on — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 199 → 99 mg/dL, hsCRP 6.0 → 1.1 mg/L. All on tirzepatide for 15 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.