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Evidence-based GLP-1 & peptide discussion since 2023
Forumsβ€ΊLab Results & Biomarkersβ€ΊSHBG changes during weight loss on GLP-1 β€” need advice β€Ί Page 2

SHBG changes during weight loss on GLP-1 β€” need advice

TirzTom Thu, Feb 8, 2024 at 2:05 AM 53 replies 3,010 viewsPage 2 of 11
ChrisMacros
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Feb 8, 2024 at 4:55 AM#6

The sleep piece resonates hard with me. I'm a nurse doing 12-hour night shifts and my weight loss has been slower than most people I see posting here. I average about 5 hours of broken sleep on work days. I wonder how much that's holding me back.

Last edited: Feb 8, 2024 at 7:55 AM
3 21RunnerRach, TrialNerd_Beth, HPLC_Greg
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LindaRN_retired
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Dec 2024
Sarasota, FL
Feb 8, 2024 at 5:12 AM#7

Sleep deprivation is enormously underappreciated as a factor in weight management. There are studies showing that people in a caloric deficit who sleep 5.5 hours lose 55% less fat and 60% more lean mass compared to those sleeping 8.5 hours β€” same caloric intake. Shift workers consistently show higher rates of obesity, metabolic syndrome, and cardiovascular disease, and disrupted circadian rhythm is a major contributor.

I know you can't always control your schedule, but even small improvements β€” blackout curtains, consistent wake times on days off, limiting caffeine 8+ hours before sleep β€” can help.

39 21Dr.GutHealth, amsterdam_pete, LondonLisa and 36 others
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Dr.NateNeph
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Houston, TX
Feb 8, 2024 at 5:29 AM#8

Looking at the OP's numbers from a trends perspective: the "plateau" from week 14-19 actually shows a slight downward trend if you plot it. 222 β†’ 219 over 5 weeks is about 0.6 lbs/week. That's not zero β€” it's just much slower than the 2.3-3.0 lbs/week she was losing before.

Psychologically, going from 3 lbs/week to 0.6 lbs/week feels like a plateau even though progress is technically still happening. This is why I always recommend plotting a 7-day moving average rather than looking at individual weigh-ins. Daily weight fluctuations of 2-4 lbs are completely normal due to water, sodium, and digestive contents.

Last edited: Feb 8, 2024 at 7:29 AM
16 0SteveThurs, B12Beth, RickReta_CO and 13 others
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