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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCOA & Analytical TestingLC-MS/MS vs HPLC for peptide analysis — November 2025 Page 4

LC-MS/MS vs HPLC for peptide analysis — November 2025

pat_auckland Wed, Apr 1, 2026 at 10:13 AM 19 replies 1,044 viewsPage 4 of 4
pat_auckland
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Apr 1, 2026 at 3:53 PM#16

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on LC-MS/MS vs HPLC for.

To answer Dr.SleepRoch: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

45 19NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 42 others
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BiostatsBrad
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Jul 2024
Durham, NC
Apr 1, 2026 at 4:10 PM#17

Relevant to LC-MS/MS vs HPLC for peptide — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 211 → 111 mg/dL, hsCRP 6.0 → 1.1 mg/L. All on tirzepatide for 15 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

22 3Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 19 others
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mark_tokyo
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Jun 2024
Tokyo, JP
Apr 1, 2026 at 4:27 PM#18

Yep. My endo said the same thing about LC-MS/MS vs HPLC for.

48 10LibrarianMeg, bri_stats, pete_manc_UK and 45 others
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Dr.GutHealth
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Mar 2024
Minnesota
Apr 1, 2026 at 4:44 PM#19

Slightly tangential to LC-MS/MS vs HPLC for but anna.melb_AU reminded me — has the insurance landscape changed recently?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

43 18Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 40 others
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Dr.PeteFamMed
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Jan 2024
Minneapolis, MN
Apr 1, 2026 at 5:01 PM#20
pat_auckland said:
Thank you all for the thoughtful replies on LC-MS/MS vs HPLC for

This is exactly right. pat_auckland articulated what I have been trying to explain to my friends for months. The LC-MS/MS vs HPLC for aspect is what made the difference for me.

8 14FranDenver, Dr.BariatricHTX, LindaRN_retired and 5 others
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