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ForumsSide Effects & ManagementGLP-1 and menstrual irregularity — my results so far Page 6

GLP-1 and menstrual irregularity — my results so far

mike_mealprep Tue, Nov 18, 2025 at 11:39 AM 29 replies 1,414 viewsPage 6 of 6
marcus_mpls
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Minneapolis, MN
Nov 18, 2025 at 8:09 PM#26

Same experience here with GLP-1 and menstrual. MaxMetOK described it perfectly.

Last edited: Nov 19, 2025 at 1:09 AM
23 4bbq_ray_KC, oliver_london, tane_welly and 20 others
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JennaRN
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Nov 18, 2025 at 8:26 PM#27
TrialNerd_Beth said:
I started my GLP-1 journey in October 2024 at 256 lbs with prediabetes and hypertension

Gonna push back on this one. GLP-1 and menstrual irregularity is not that straightforward in my experience. I have been on this for 18 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But adherence is harder than people admit. We should be honest about that.

11 1PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 8 others
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SkepticalSean
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Jan 2025
Maine
Nov 18, 2025 at 8:43 PM#28

Want to share my personal experience related to GLP-1 and menstrual since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 262 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 18 months later: I am down 37 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The GLP-1 and menstrual aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

44 6emma_london, tammy_FL, Dr.LipidDallas and 41 others
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bri_stats
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Seattle, WA
Nov 18, 2025 at 9:00 PM#29

Saving this for reference. Quality thread.

Last edited: Nov 19, 2025 at 1:00 AM
21 9JessicaM_2024, TomFromTexas, mike.trainer_LA and 18 others
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raj_cambridge
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Jun 2024
Cambridge, MA
Nov 18, 2025 at 9:17 PM#30

marcus_mpls — that is really helpful context on GLP-1 and menstrual. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

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