Why does sema make me SO tired??

COA_Karl

Senior Member

2,123

8,901

Jan 2024

Pennsylvania

Apr 1, 2026 at 1:24 PM#6

PharmD_Rodriguez said:
— I actually dealt with this exact situation around month 3

Gonna push back on this one. Why does sema make me SO tired?? is not that straightforward in my experience. I have been on this for 18 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But adherence is harder than people admit. We should be honest about that.

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Dr.PulmRoch

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456

2,345

Jun 2024

Rochester, MN

Apr 1, 2026 at 1:41 PM#7

Adding my data to this Why does sema make me SO discussion:

Metric	Baseline	Month 3	Month 8
Weight	266 lbs	226 lbs	201 lbs
A1C	7.0%	5.8%	5.4%
hsCRP	5.0	2.0	0.8

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.3g/kg/day.

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emma_london

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Oct 2024

London, UK

Apr 1, 2026 at 1:58 PM#8

roxy_nash — wow. I've been looking for this exact info for weeks.

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B12Beth

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Oct 2024

Maryland

Apr 1, 2026 at 2:15 PM#9

Slightly tangential to Why does sema make me SO but carlos_SATX reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

40 8marco_milano, pam_columbus, nick_SD_fit and 37 others

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