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ForumsClinical Trials & ResearchSTEP-HFpEF-DM: semaglutide in HFpEF with diabetes — what worked for you? Page 3

STEP-HFpEF-DM: semaglutide in HFpEF with diabetes — what worked for you?

B12Beth Thu, Jan 15, 2026 at 4:40 PM 11 replies 965 viewsPage 3 of 3
RetaRick_CA
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Jan 15, 2026 at 8:55 PM#11
LibrarianMeg said:
STEP-HFpEF-DM semaglutide in HFpEF is not that straightforward in my experience

This is exactly right. LibrarianMeg articulated what I have been trying to explain to my friends for months. The STEP-HFpEF-DM semaglutide aspect is what made the difference for me.

14 15SkepticalSean, Dr.CardioMD, EndoResFellow and 11 others
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Dr.RenalNash
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Jan 15, 2026 at 9:12 PM#12

Reading this thread on STEP-HFpEF-DM semaglutide hits close to home. Dad of 2 checking in — I started at 265 lbs and felt like I would tried everything.

11 months on tirz and I am a different person. Not just the 40 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about STEP-HFpEF-DM — take the leap. It was the best health decision I have ever made. ❤️

Last edited: Jan 16, 2026 at 2:12 AM
14 7pam_stl, wei_SG, cory_ATX and 11 others
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NauseaFreeNow
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Jan 15, 2026 at 9:29 PM#13

NurseKim_ATL — that is really helpful context on STEP-HFpEF-DM semaglutide. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

Last edited: Jan 16, 2026 at 1:29 AM
17 22Dr.PulmRoch, maya_sedona, stefan_berlin and 14 others
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JenPlateau
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Jan 15, 2026 at 9:46 PM#14

To answer Dr.RenalNash's question specifically:

From a clinical standpoint, STEP-HFpEF-DM semaglutide in is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

4 20FitDadDave, RunnerRach, TrialNerd_Beth and 1 other
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maria_elpaso
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Jan 15, 2026 at 10:03 PM#15

Bookmarked 📌 The STEP-HFpEF-DM info in this thread is essential. Coming back to this for sure.

34 24LibrarianMeg, bri_stats, pete_manc_UK and 31 others
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