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ForumsCardiovascular OutcomesSOUL trial preliminary data — November 2025

SOUL trial preliminary data — November 2025

JenMemphis Sun, Mar 16, 2025 at 2:50 AM 51 replies 2,130 viewsPage 1 of 11
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JenMemphis
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Mar 16, 2025 at 4:15 AM#1

Anyone else dealing with soul trial preliminary data november 2025 from a cost perspective?

I have been paying $280/month and I am trying to get insurance to cover it.

Share what you are paying and what you are getting — transparency helps everyone.

42 4MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 39 others
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TrialNerd_Beth
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Mar 16, 2025 at 4:32 AM#2
JenMemphis said:
SOUL trial preliminary data November 2025

I respect JenMemphis perspective but I think this oversimplifies things a bit. Re: SOUL trial preliminary data — the effect size varies considerably by population.

I am not saying JenMemphis wrong entirely — just that the picture is more nuanced than a blanket statement. The SURMOUNT data specifically shows baseline BMI-dependent responses.

Last edited: Mar 16, 2025 at 8:32 AM
16 20PharmHunterJen, TomTeleRx, DoseLogDan and 13 others
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TirzTom
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Mar 16, 2025 at 4:49 AM#3

+1 to JenMemphis. Especially the point about "SOUL trial preliminary data November 20..." — I have seen the same in my own experience with SOUL trial preliminary.

Last edited: Mar 16, 2025 at 8:49 AM
45 6Dr.EndoIndy, tom_AK, josh_phd_bmore and 42 others
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Dr.Martinez
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Mar 16, 2025 at 5:06 AM#4

As a healthcare provider, I want to add some clinical context to this discussion on SOUL trial preliminary data November.

Building on what JenMemphis said — the evidence base here is well-established. The key publications to reference are from the SURMOUNT program[1].

Key clinical points:

  1. Efficacy is dose-dependent and typically requires 4-5 weeks to reach steady state
  2. Side effect profile is predictable and usually manageable with standard protocols
  3. Monitoring should include baseline labs and follow-up at 3-month intervals
  4. Patient education significantly improves outcomes and adherence

Standard disclaimer: this is educational, not individualized medical advice.

References:
[1] See thread title for relevant study identification.
19 23Dr.SurgeonPGH, rachel_ABQ, traveltech_sara and 16 others
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Dr.NutriCornell
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Mar 16, 2025 at 5:23 AM#5
TirzTom said:
Especially the point about "SOUL trial preliminary data November 20

Gonna push back on this one. SOUL trial preliminary data is not that straightforward in my experience. I have been on this for 18 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But adherence is harder than people admit. We should be honest about that.

30 6pat_auckland, Dr.GastroMayo, JakeBK_lifts and 27 others
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