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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCardiovascular OutcomesHeart rate increase on GLP-1 — 6 month update Page 3

Heart rate increase on GLP-1 — 6 month update

FDA_TrackerJim Wed, Mar 26, 2025 at 3:23 PM 12 replies 1,604 viewsPage 3 of 3
sarah.morrison
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Mar 26, 2025 at 7:38 PM#11
TrialTracker_MD said:
Heart rate increase on GLP-1 6 is not that straightforward in my experience

This is exactly right. TrialTracker_MD articulated what I have been trying to explain to my doctor for months. The Heart rate increase on aspect is the most important factor.

41 14josh_phd_bmore, roxy_nash, tony_orlando and 38 others
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SteveThurs
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Mar 26, 2025 at 7:55 PM#12

Reading this thread on Heart rate increase on hits close to home. Night shift nurse — I started at 279 lbs and felt like I would tried everything.

15 months on tirz and I am a different person. Not just the 54 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Heart rate increase — take the leap. It was the best health decision I have ever made. ❤️

24 16PurityPaulOR, MaxMetOK, MounjBrad and 21 others
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tommy_boulder
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Mar 26, 2025 at 8:12 PM#13

DeniseRN_TPA — that is really helpful context on Heart rate increase on. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

9 20robert_kc, dan_philly, MeganSA_TX and 6 others
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Dr.RenalNash
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Mar 26, 2025 at 8:29 PM#14

To answer SteveThurs's question specifically:

From a clinical standpoint, Heart rate increase on GLP-1 is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

46 17anders_CPH, Dr.NutriCornell, pam_stl and 43 others
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james_edin
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Mar 26, 2025 at 8:46 PM#15

Bookmarked 📌 The Heart rate increase info in this thread is essential. Coming back to this for sure.

Last edited: Mar 26, 2025 at 10:46 PM
2 6bbq_ray_KC, oliver_london
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