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ForumsTirzepatide (Mounjaro / Zepbound)SURMOUNT-5: Tirzepatide vs semaglutide head-to-head — November 2025 Page 7

SURMOUNT-5: Tirzepatide vs semaglutide head-to-head — November 2025

LabKate Sat, Mar 14, 2026 at 9:46 PM 36 replies 1,552 viewsPage 7 of 8
NauseaFreeNow
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Mar 15, 2026 at 7:41 AM#31

Same experience here with SURMOUNT-5 Tirzepatide vs. NeuroNate described it perfectly.

44 3stefan_berlin, Dr.EM_Chicago, pete_RVA and 41 others
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PeptideSynthNJ
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Mar 15, 2026 at 7:58 AM#32

+1 to NurseLeah_Nash. Especially the point about "Follow-up question: did you change anyth..." — I have seen the same in my own experience with SURMOUNT-5 Tirzepatide vs.

Last edited: Mar 15, 2026 at 11:58 AM
25 15NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 22 others
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LabKate
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Mar 15, 2026 at 8:15 AM#33

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on SURMOUNT-5 Tirzepatide vs.

To answer LabKate: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

31 10Dr.SleepRoch, laura_annarbor, JenMemphis and 28 others
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Dr.BariatricHTX
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Mar 15, 2026 at 8:32 AM#34

+1 to stefan_berlin. Especially the point about "The first month are the hardest..." — I have seen the same in my own experience with SURMOUNT-5 Tirzepatide vs.

33 14stefan_berlin, Dr.EM_Chicago, pete_RVA and 30 others
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pete_RVA
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Mar 15, 2026 at 8:49 AM#35

100%. My provider said the same thing about SURMOUNT-5 Tirzepati.

11 21Dr.LeslieOBGYN, MikeNYC_runner and 8 others
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