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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsHas anyone dealt with dropped my rybelsus in the toilet this morning - worst day? Page 5

Has anyone dealt with dropped my rybelsus in the toilet this morning - worst day?

MASHdoc_SA Tue, Jul 9, 2024 at 9:49 AM 41 replies 2,586 viewsPage 5 of 9
hyun_seoul
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Jul 2024
Seoul, KR
Jul 9, 2024 at 4:54 PM#21

paul_denver — that is really helpful context on Has anyone dealt with. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

43 8Dr.ObesityMed, HealthEcon_DC, PedsEndoPhilly and 40 others
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Dr.CardioMD
VIP Member
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14,567
Dec 2023
Cleveland, OH
Jul 9, 2024 at 5:11 PM#22

To answer Admin's question specifically:

From a clinical standpoint, Has anyone dealt with dropped is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

46 20Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 43 others
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robert_kc
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Oct 2024
Kansas City, MO
Jul 9, 2024 at 5:28 PM#23

Thank you hyun_seoul! This is incredibly helpful. Bookmarking for later. 🙏

Last edited: Jul 9, 2024 at 7:28 PM
6 17DoseLogDan, SleepFixSam, PurityPaulOR and 3 others
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wendy_avl
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1,123
Oct 2024
Asheville, NC
Jul 9, 2024 at 5:45 PM#24

Relevant to Has anyone dealt with dropped — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 209 → 109 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

10 9PharmHunterJen, TomTeleRx, DoseLogDan and 7 others
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cory_ATX
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456
2,123
Jul 2024
Austin, TX
Jul 9, 2024 at 6:02 PM#25

Slightly tangential to Has anyone dealt with but hyun_seoul reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

37 8tane_welly, Dr.PathRoch, mona_PHX and 34 others
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