🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsHas anyone dealt with rybelsus real-world vs clinical trial efficacy? Page 5

Has anyone dealt with rybelsus real-world vs clinical trial efficacy?

NeuroNate Sat, Oct 19, 2024 at 12:13 AM 31 replies 2,377 viewsPage 5 of 7
FranDenver
Member
267
1,123
Oct 2024
Denver, CO
Oct 19, 2024 at 7:18 AM#21

DerekSJ_a1c — that is really helpful context on Has anyone dealt with. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

Last edited: Oct 19, 2024 at 1:18 PM
16 21Dr.RenalNash, LipidDoc_ATL, BariatricNurseD and 13 others
Reply Quote Save Share Report
Dr.CardioMD
VIP Member
2,678
14,567
Dec 2023
Cleveland, OH
Oct 19, 2024 at 7:35 AM#22

To answer CryptoCarl's question specifically:

From a clinical standpoint, Has anyone dealt with rybelsus is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

40 9Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 37 others
Reply Quote Save Share Report
paige_pharma
Member
289
1,234
Sep 2024
Omaha, NE
Oct 19, 2024 at 7:52 AM#23

Thank you FranDenver! This is incredibly helpful. Bookmarking for later. 🙏

45 8adam_van, Dr.SurgeonPGH, rachel_ABQ and 42 others
Reply Quote Save Share Report

PeptideMeter — Independent Peptide Analytics

Community-driven peptide testing and vendor rating platform. Transparent results. Unbiased analysis. Trusted by thousands.

View Results
PharmacoVig_BOS
Senior Member
1,567
8,901
Feb 2024
Boston, MA
Oct 19, 2024 at 8:09 AM#24

Relevant to Has anyone dealt with rybelsus — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 233 → 103 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

3 14kate.chem, DataDave, Dr.GutHealth
Reply Quote Save Share Report
GraceAZ_72
Member
156
678
Jan 2025
Tucson, AZ
Oct 19, 2024 at 8:26 AM#25

Slightly tangential to Has anyone dealt with but FranDenver reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Oct 19, 2024 at 12:26 PM
26 23RetaRick_CA, JenPlateau, SallyK_inj and 23 others
Reply Quote Save Share Report

Similar Threads

Orforglipron Phase 3 ATTAIN-1 topline — oral non-peptide GLP-116 replies
Oral semaglutide 50mg (Rybelsus HD) — OASIS program results12 replies
Danuglipron BID dosing — Pfizer oral GLP-1 update7 replies
Oral vs injectable GLP-1: bioavailability and efficacy comparison5 replies
Orforglipron food interaction profile — no fasting requirement15 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register