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Forumsβ€ΊPublic Squareβ€ΊMuscle protein synthesis rates on GLP-1 β€” leucine threshold discussion β€Ί Page 4

Muscle protein synthesis rates on GLP-1 β€” leucine threshold discussion

ChrisMacros Mon, May 25, 2026 at 8:37 AM 21 replies 460 viewsPage 4 of 5
ChrisMacros
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May 25, 2026 at 2:17 PM#16

OP here β€” wow, did not expect this much response! Thank you all for the thoughtful replies on Muscle protein synthesis.

To answer SarahChen_PharmD: my doctor and I discussed the options and went with brand.

Quick update: I have noticed more improvement since posting this. Thanks again for the evidence-based discussion β€” this is exactly why I posted in a science-based community. πŸ™

31 7RunnerRach, TrialNerd_Beth, HPLC_Greg and 28 others
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SleepDoc_PDX
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Portland, OR
May 25, 2026 at 2:34 PM#17

Adding my data to this Muscle protein synthesis discussion:

MetricBaselineMonth 3Month 6
Weight276 lbs216 lbs201 lbs
A1C7.0%5.8%5.2%
hsCRP5.02.01.0

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.3g/kg/day.

Last edited: May 25, 2026 at 5:34 PM
48 8hank_denver, carlos_SATX, sophie_paris and 45 others
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fiona_VT
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Vermont
May 25, 2026 at 2:51 PM#18

Exactly this. My pharmacist said the same thing about Muscle protein.

Last edited: May 25, 2026 at 3:51 PM
33 5jason_sac26, chris_chi24, tampaLisa73 and 30 others
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Dr.KarenChen
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May 25, 2026 at 3:08 PM#19

Slightly tangential to Muscle protein synthesis but ben_calgary reminded me β€” what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered β€” I did search first.

Last edited: May 25, 2026 at 9:08 PM
13 17mike.trainer_LA, sarah_nash92, FitDadDave and 10 others
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JakeSmashed95
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May 25, 2026 at 3:25 PM#20

+1 to ChrisMacros. Especially the point about "Thank you all for the thoughtful replies..." β€” I have seen the same in my own experience with Muscle protein synthesis.

46 1tammy_FL, Dr.LipidDallas, alex_tucson and 43 others
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