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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsOral sema empty stomach requirement — how strict is it really? Page 4

Oral sema empty stomach requirement — how strict is it really?

mike_nyc Sat, May 23, 2026 at 7:04 AM 23 replies 496 viewsPage 4 of 5
mike_nyc
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May 23, 2026 at 12:44 PM#16

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Oral sema empty stomach.

To answer SkepticalSean: my doctor and I discussed the options and went with brand.

Quick update: I have noticed more improvement since posting this. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

28 10maya_sedona, stefan_berlin, Dr.EM_Chicago and 25 others
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Dr.PulmRoch
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May 23, 2026 at 1:01 PM#17

Adding my data to this Oral sema empty stomach discussion:

MetricBaselineMonth 3Month 6
Weight248 lbs243 lbs213 lbs
A1C7.2%5.8%5.2%
hsCRP7.02.00.6

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.5g/kg/day.

Last edited: May 23, 2026 at 2:01 PM
41 21traveltech_sara, AttorneyGrant, DebRD_ATL and 38 others
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WendyG_ATL
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May 23, 2026 at 1:18 PM#18

Exactly this. My pharmacist said the same thing about Oral sema empty.

Last edited: May 23, 2026 at 2:18 PM
25 11traveltech_sara, AttorneyGrant, DebRD_ATL and 22 others
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DataDave
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May 23, 2026 at 1:35 PM#19

Slightly tangential to Oral sema empty stomach but COA_Karl reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: May 23, 2026 at 2:35 PM
29 6amsterdam_pete, LondonLisa, mike_nyc and 26 others
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mark_tokyo
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May 23, 2026 at 1:52 PM#20

+1 to mike_nyc. Especially the point about "Thank you all for the thoughtful replies..." — I have seen the same in my own experience with Oral sema empty stomach.

32 11TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 29 others
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