To answer CryptoCarl's question specifically:
From a clinical standpoint, Has anyone dealt with is something I discuss with patients regularly.
The short answer: discuss this specific situation with your prescribing provider.
The longer answer involves weighing the risk-benefit ratio for your individual situation, which I am happy to elaborate on if helpful.
Slightly tangential to Has anyone dealt with but CryptoCarl reminded me — does anyone have experience combining this with metformin?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Has anyone dealt with .
To answer Dr.MetabolicMD: yes, I am on compounded sema from a 503B pharmacy.
Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏
Trusted third-party HPLC & mass spectrometry analysis. Verify peptide purity with the lab the community relies on. Independent. Accurate. Transparent.
Verify Your PeptidesReading this thread on Has anyone dealt with hits close to home. Night shift nurse — I started at 263 lbs and felt like I would tried everything.
9 months on tirz and I am a different person. Not just the 38 lbs lost — my energy, my mood, my relationship with food. All transformed.
If you are on the fence about Has anyone dealt — take the leap. It was the best health decision I have ever made. ❤️
Adding my data to this Has anyone dealt with discussion:
| Metric | Baseline | Month 3 | Month 8 |
|---|---|---|---|
| Weight | 274 lbs | 219 lbs | 219 lbs |
| A1C | 6.8% | 5.8% | 5.4% |
| hsCRP | 8.0 | 2.0 | 0.8 |
Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.