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Evidence-based GLP-1 & peptide discussion since 2023
ForumsDosing & ProtocolsHas anyone dealt with splitting doses? Page 5

Has anyone dealt with splitting doses?

DebRD_ATL Fri, Oct 18, 2024 at 4:21 PM 22 replies 1,985 viewsPage 5 of 5
tane_welly
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Wellington, NZ
Oct 18, 2024 at 11:26 PM#21

amsterdam_pete — that is really helpful context on Has anyone dealt with. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

14 20GraceAZ_72, carl_compliance, DanielChem_CHI and 11 others
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Dr.BariatricHTX
Senior Member
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Feb 2024
Houston, TX
Oct 18, 2024 at 11:43 PM#22

To answer lisa_labSD's question specifically:

From a clinical standpoint, Has anyone dealt with is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

18 12pete_RVA, CarlaRPh_TPA, steph_laguna and 15 others
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mike_nyc
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New York
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Oct 19, 2024 at 12:00 AM#23

Thank you tane_welly! This is incredibly helpful. Taking this to my next appointment. 🙏

Last edited: Oct 19, 2024 at 4:00 AM
44 18Dr.EM_Chicago, pete_RVA, CarlaRPh_TPA and 41 others
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NicoleRaleigh
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Aug 2024
Raleigh, NC
Oct 19, 2024 at 12:17 AM#24

Relevant to Has anyone dealt with — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 207 → 107 mg/dL, hsCRP 6.0 → 1.3 mg/L. All on tirzepatide for 11 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

23 21VendorMark, COA_Karl, MikeFit_NJ and 20 others
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RunnerRach
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Aug 2024
Boston, MA
Oct 19, 2024 at 12:34 AM#25

Slightly tangential to Has anyone dealt with but tane_welly reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

18 15tyler_CSCS, VanRx_Mike, steve_okc and 15 others
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