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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsPeptide degradation pathways — anyone have experience? Page 6

Peptide degradation pathways — anyone have experience?

lori_vegas Tue, Nov 18, 2025 at 12:24 PM 26 replies 1,236 viewsPage 6 of 6
MariaRD
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Jun 2024
New Mexico
Nov 18, 2025 at 8:54 PM#26

TomTeleRx — that is really helpful context on Peptide degradation. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

45 4Dr.NutriCornell, pam_stl, wei_SG and 42 others
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Dr.RheumBOS
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Apr 2024
Boston, MA
Nov 18, 2025 at 9:11 PM#27

Reading this thread on Peptide degradation hits close to home. Dad of 2 checking in — I started at 289 lbs and felt like I would tried everything.

15 months on tirz and I am a different person. Not just the 64 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Peptide degradation — take the leap. It was the best health decision I have ever made. ❤️

34 5wei_SG, cory_ATX, lori_vegas and 31 others
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mel_PDX
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Portland, OR
Nov 18, 2025 at 9:28 PM#28

Congrats lori_vegas!! Keep going — you're doing incredible. 🎉 👏

5 15PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 2 others
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LabKate
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Jan 2024
Oregon
Nov 18, 2025 at 9:45 PM#29

Exactly this. My pharmacist said the same thing about Peptide degradation.

Last edited: Nov 19, 2025 at 12:45 AM
23 20emily_PDX, Dr.SleepRoch, laura_annarbor and 20 others
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PurityPaulOR
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Oregon
Nov 18, 2025 at 10:02 PM#30

Congrats lori_vegas!! You should be so proud of yourself. 🎉

46 11mike_mod, SarahChen_PharmD, sarah.morrison and 43 others
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